A totem pole power factor correction circuit is provided. The detection module in the totem pole power factor correction circuit includes a detection resistor and a detection circuit. If the output voltage outputted by the detection circuit is greater than or equal to an upper limit voltage threshold or lower than or equal to a lower limit voltage threshold, at least a third switch and a fourth switch are turned off under control of the control unit. Consequently, the totem pole power factor correction circuit can be protected. Under this circumstance, the protecting measure can be taken immediately. Consequently, the possibility of causing damage of the totem pole power factor correction circuit will be minimized. In other words, the performance of the totem pole power factor correction circuit is enhanced.