- 专利标题： CHIMERIC ANTIGEN RECEPTOR WITH MODIFIED HINGE REGION AND USES THEREOF
-
申请号： US18050461申请日： 2022-10-27
-
公开(公告)号： US20230381230A1公开(公告)日： 2023-11-30
- 发明人: BUO CHEN , Xiangqun LI , Ang Zhang
- 申请人： BUO CHEN , Xiangqun LI , Ang Zhang
- 申请人地址： US TX KATY
- 专利权人： Orgenesis Inc.,Broaden BioScience and Technology Corp.
- 当前专利权人： Orgenesis Inc.,Broaden BioScience and Technology Corp.
- 当前专利权人地址： US MD Germantown; US TX Katy
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C07K14/705 ; A61K39/00 ; C12N5/0783
摘要：
The present disclosure provides a chimeric antigen receptor (CAR) molecule comprising a modified hinge domain, wherein the hinge domain comprises the amino acid sequence of SEQ ID NO:1. Cells expressing a CAR comprising the modified hinge domain disclosed herein are shown to have enhanced anti-tumor activities with reduced release of pro-inflammatory cytokines.
信息查询
IPC分类:
