发明公开
- 专利标题： REACTIVE CONJUGATES
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申请号： US18248674申请日： 2021-10-12
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公开(公告)号： US20230381327A1公开(公告)日： 2023-11-30
- 发明人: Léo MARX , Viktoriia POSTUPALENKO , Origéne Franz NYANGUILE , Jean-Manuel SEGURA , Mathilde Lucile Colette PANTIN , Patrick GARROUSTE , Frederic LEVY
- 申请人： DEBIOPHARM RESEARCH & MANUFACTURING S.A.
- 申请人地址： CH Martigny
- 专利权人： DEBIOPHARM RESEARCH & MANUFACTURING S.A.
- 当前专利权人： DEBIOPHARM RESEARCH & MANUFACTURING S.A.
- 当前专利权人地址： CH Martigny
- 优先权： WO TEP2020078571 2020.10.12
- 国际申请： PCT/EP2021/078181 2021.10.12
- 进入国家日期： 2023-04-11
- 主分类号： A61K47/64
- IPC分类号： A61K47/64 ; A61K47/60 ; A61K49/10 ; A61K49/14 ; A61K49/00 ; A61K47/68
摘要：
The present invention relates to compounds (reactive conjugates) for the chemical modification of therapeutic antibodies or proteins. The compounds enable the regioselective attachment of payloads to an antibody or antibody fragment in one single step, thereby producing a modified antibody or modified antibody fragment, which can be used for diagnosing, monitoring, imaging or treating disease.
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