A medical information processing system of an embodiment includes a processing circuit. The processing circuit acquires examination data showing medical examination results with respect to a medical treatment subject and reply data showing reply results of a medical examination by interview with respect to the medical treatment subject. The processing circuit estimates information on medical treatment of the medical treatment subject by inputting the examination data of the medical treatment subject to a first model and estimates information on medical treatment of the medical treatment subject by inputting the examination data and the reply data of the medical treatment subject to a second model. The processing circuit outputs a first estimation result of the first model and a second estimation result of the second model via an output unit.