- 专利标题： SUBSTANCE INTERACTING WITH C TERMINAL FRAGMENT OF THE STIM1 FRACTION LOCALIZED TO THE PLASMA MEMBRANE OF THE CELLS, FOR ITS USE IN THE TREATMENT OF CANCERS, AND IN SCREENING AND DIAGNOSTIC METHODS
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申请号： US17442640申请日： 2020-03-23
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公开(公告)号： US20230063059A1公开(公告)日： 2023-03-02
- 发明人: OLIVIER MIGNEN , PAUL BUSCAGLIA , PATRICE HEMON , NELIG LE GOUX
- 申请人： UNIVERSITÉ DE BRETAGNE OCCIDENTALE - UBO , CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST , INSERM-INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
- 申请人地址： FR BREST; FR BREST; FR PARIS
- 专利权人： UNIVERSITÉ DE BRETAGNE OCCIDENTALE - UBO,CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST,INSERM-INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
- 当前专利权人： UNIVERSITÉ DE BRETAGNE OCCIDENTALE - UBO,CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST,INSERM-INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
- 当前专利权人地址： FR BREST; FR BREST; FR PARIS
- 优先权： EP19305374.1 20190325
- 国际申请： PCT/EP2020/057916 WO 20200323
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; G01N33/574 ; G01N33/50 ; A61K31/7068 ; A61P35/00 ; A61P1/18 ; A61K39/395
摘要：
The present invention relates to a substance interacting with C terminal fragment of the STIM1 fraction localized to the plasma membrane of the cells, for its use in the treatment of cancers. The present invention further relates to a pharmaceutical composition comprising at least one substance interacting with C terminal fragment of the STIM1 fraction localized to the plasma membrane of cells, and at least one pharmaceutically acceptable excipient. The invention also refers to the use of isolated C terminal fragment of the STIM1 fraction localized to the plasma membrane of cells in a method for screening candidate molecules for treating cancers, especially pancreatic, colon, breast, Burkitt lymphoma or chronic Lymphocytic Leukaemia. The present invention also relates to a process for predicting the progression and/or monitoring the progression of a cancer, comprising the in vitro detection of the expression of STIM1 in a sample of the tumour of the subject.
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