A method of controlling a robot manipulator, the method including: providing a database containing body zones of a person, wherein each of the body zones is assigned a respective maximum permissible value of contact pressure value, determining a current or a future contact event of the robot manipulator involving the person, and determining a body zone of the person that is contacted, determining a reference position fixed relative to a body of the person, wherein the reference position indicates beginning of a spatial progression of depression of tissue of the person during the contact event with the person, and controlling the robot manipulator in an impedance-regulated manner, such that the reference position serves as a zero position of an artificial spring component of impedance regulation of the robot manipulator and a maximum permissible contact pressure is not exceeded as a limit value.