A method for removing tube wave interference from optical fiber acoustic wave sensing seismic data, including: acquiring seismic wavefield data which contains a tube wave and is collected by an optical fiber acoustic wave sensing instrument; calculating a root-mean-square amplitude of the waveform data cut on the seismic trace as an amplitude normalization factor; performing normalization processing on the amplitude value; performing de-tail mean filtering processing on the normalized amplitude value along the travel time of the tube wave, to obtain a predicted amplitude value; performing tube wave interference removal processing on each seismic trace, and performing inverse normalization processing to obtain the seismic wavefield data without tube wave interference. The method effectively suppresses the tube wave interference in the optical fiber acoustic wave sensing seismic data. An apparatus for removing tube wave interference from optical fiber acoustic wave sensing seismic data, and a computer device are further provided.