- 专利标题： CRISPR-BASED ASSAY FOR DETECTING TB IN BODILY FLUIDS
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申请号： US17797425申请日： 2021-02-05
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公开(公告)号： US20230087018A1公开(公告)日： 2023-03-23
- 发明人: Tony Ye HU , Bo NING , Zhen HUANG
- 申请人： The Administrators of the Tulane Educational Fund
- 申请人地址： US LA New Orleans
- 专利权人： The Administrators of the Tulane Educational Fund
- 当前专利权人： The Administrators of the Tulane Educational Fund
- 当前专利权人地址： US LA New Orleans
- 国际申请： PCT/US21/16931 WO 20210205
- 主分类号： C12Q1/689
- IPC分类号： C12Q1/689 ; C12Q1/686 ; C12N15/10
摘要：
The present disclosure describes a method for detecting the presence of Mycobacterium tuberculosis in a bodily fluid sample. The method utilizes CRISPR effector proteins along with a guide RNA and a reporter molecule, such that when the guide RNA hybridizes with a target nucleotide fragment, the CRISPR effector protein cleaves the reporter molecule, resulting in a detectable signal.
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