- 专利标题: INTERMEDIATE USEFUL FOR SYNTHESIS OF SGLT INHIBITOR AND METHOD FOR PREPARING SGLT INHIBITOR USING SAME
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申请号: US17799054申请日: 2021-02-26
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公开(公告)号: US20230096670A1公开(公告)日: 2023-03-30
- 发明人: Youn Jung YOON , Hee Kyoon YOON
- 申请人: Daewoong Pharmaceutical Co., Ltd.
- 申请人地址: KR Hwaseong-si Gyeonggi-do
- 专利权人: Daewoong Pharmaceutical Co., Ltd.
- 当前专利权人: Daewoong Pharmaceutical Co., Ltd.
- 当前专利权人地址: KR Hwaseong-si Gyeonggi-do
- 优先权: KR10-2020-0024525 20200227
- 国际申请: PCT/KR2021/002507 WO 20210226
- 主分类号: C07D407/04
- IPC分类号: C07D407/04 ; C07D307/79
摘要:
An intermediate useful for the synthesis of an SGLT inhibitor and a method for preparing an SGLT inhibitor are provided. By employing an intermediate having Chemical Formula 5, the difficulty of purification with existing processes can be solved, the quality requirements for related substances can be achieved with only one purification step, and the quality control problem in each step can be solved by performing several steps in situ. A method for synthesizing a compound of Chemical Formula 1 by using a compound of Chemical Formula 5 enables purification in an earlier step, thereby solving the problems of existing synthesis processes, in which the quality requirements for related substances were difficult to control step-by-step due to a continuous process, thereby minimizing the amount of related substances in the final product. In addition, the yield of a diphenylmethane derivative according to Chemical Formula 1 is increased.
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