A pixel structure, a display substrate and a driving method therefor, and a display device. The pixel structure includes a plurality of pixel units; each pixel unit comprises a first sub-pixel, a second sub-pixel, a third sub-pixel, and a central sub-pixel; the central sub-pixel is located in an area enclosed by the first sub-pixel, the second sub-pixel, and the third sub-pixel; the minimum distance from the central sub-pixel to at least one of the first sub-pixel, the second sub-pixel, and the third sub-pixel in a same pixel unit is less than the distance between two adjacent pixel units.