- 专利标题： SARS-COV-2 VACCINE
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申请号： US17798021申请日： 2021-02-11
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公开(公告)号： US20230113170A1公开(公告)日： 2023-04-13
- 发明人: Barney Graham , Kizzmekia Corbett , Olubukola Abiona , Geoffrey Hutchinson , Jason McLellan , Daniel Wrapp , Nianshuang Wang
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human , Board of Regents, The University of Texas System , Trustees of Dartmouth College
- 申请人地址： US MD Bethesda; US TX Austin; US NH Hanover
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human,Board of Regents, The University of Texas System,Trustees of Dartmouth College
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human,Board of Regents, The University of Texas System,Trustees of Dartmouth College
- 当前专利权人地址： US MD Bethesda; US TX Austin; US NH Hanover
- 国际申请： PCT/US2021/017709 WO 20210211
- 主分类号： A61K39/215
- IPC分类号： A61K39/215 ; C12N15/86 ; A61P31/14
摘要：
SARS-CoV-2 S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the SARS-CoV-2 S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to SARS-CoV-2 S in a subject, for example, an immune response that inhibits SARS-CoV-2 infection in the subject.
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