发明申请
- 专利标题: CELL
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申请号: US17915637申请日: 2021-04-08
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公开(公告)号: US20230113183A1公开(公告)日: 2023-04-13
- 发明人: Callum McKenzie , Shaun Cordoba , MArtin Pulé
- 申请人: AUTOLUS LIMITED
- 申请人地址: GB London
- 专利权人: AUTOLUS LIMITED
- 当前专利权人: AUTOLUS LIMITED
- 当前专利权人地址: GB London
- 优先权: GB2005331.0 20200409,GB2017358.9 20201102
- 国际申请: PCT/GB2021/050866 WO 20210408
- 主分类号: C12N5/0783
- IPC分类号: C12N5/0783 ; C07K14/705 ; C07K14/725 ; C12N15/63
摘要:
The present invention relates to a cell which comprises; (a) a chimeric antigen receptor (CAR) or a transgenic T-cell receptor (TCR); and (b) a FasL-binding receptor (FLBR) comprising; (i) a Fas ectodomain and a TNFR endodomain, wherein the TNFR endodomain comprises the signalling portion of the decoy receptor 2 (DcR2), GITR, CD30, XEDAR, CD40, CD27, BCMA or Fn14 endodomain, or (ii) a membrane-bound decoy receptor 3 (DcR3).
公开/授权文献
- US2184347A Telemeter transmitter 公开/授权日:1939-12-26
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