- 专利标题: 2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE
-
申请号: US17786089申请日: 2020-12-18
-
公开(公告)号: US20230114875A1公开(公告)日: 2023-04-13
- 发明人: Grace EDMUND , Michael H. CHARLTON , Paul William FINN , Aigars JIRGENSONS , Marija SKVORCOVA , Janis VELIKS , Liene GRIGORJEVA
- 申请人: Oxford Drug Design Limited
- 申请人地址: GB London, Greater London
- 专利权人: Oxford Drug Design Limited
- 当前专利权人: Oxford Drug Design Limited
- 当前专利权人地址: GB London, Greater London
- 国际申请: PCT/EP2020/087126 WO 20201218
- 主分类号: C07C381/10
- IPC分类号: C07C381/10 ; C07C313/06 ; C07D277/16 ; C07D213/71 ; C07D333/34 ; C07D333/52 ; C07D307/79 ; C07D215/36 ; C07D231/18 ; C07D495/04 ; C07D317/50
摘要:
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6-sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.
信息查询