![PROCESSES OF MAKING 3-FLUORO-5-(((1S,2aR)-1,3,3,4,4-PENTAFLUORO-2a-HYDROXY-2,2a,3,4-TETRAHYDRO-1H-CYCLOPENTA[CD]INDEN-7-YL)OXY)-BENZONITRILE AND POLYMORPHS THEREOF](/docs/US/2023-04-13/US20230115881A1/abs.jpg.600x600.jpg)
- 专利标题： PROCESSES OF MAKING 3-FLUORO-5-(((1S,2aR)-1,3,3,4,4-PENTAFLUORO-2a-HYDROXY-2,2a,3,4-TETRAHYDRO-1H-CYCLOPENTA[CD]INDEN-7-YL)OXY)-BENZONITRILE AND POLYMORPHS THEREOF
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申请号： US17963926申请日： 2022-10-11
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公开(公告)号： US20230115881A1公开(公告)日： 2023-04-13
- 发明人: Charles M. COOK , Jiping FU , Yigang HE , Yan LOU , Rongzhen CHEN , Yan DONG
- 申请人： NiKang Therapeutics, Inc.
- 申请人地址： US DE Wilmington
- 专利权人： NiKang Therapeutics, Inc.
- 当前专利权人： NiKang Therapeutics, Inc.
- 当前专利权人地址： US DE Wilmington
- 优先权： CNPCT/CN2021/123248 20211012,CNPCT/CN2021/123407 20211013
- 主分类号： C07C255/54
- IPC分类号： C07C255/54 ; C07C253/34 ; A61K9/20 ; A61K9/48 ; A61K9/00 ; A61K47/26 ; A61K47/38 ; A61K47/12 ; A61K9/06 ; A61K47/10 ; A61K47/14 ; C07C253/30 ; A61K9/08
![PROCESSES OF MAKING 3-FLUORO-5-(((1S,2aR)-1,3,3,4,4-PENTAFLUORO-2a-HYDROXY-2,2a,3,4-TETRAHYDRO-1H-CYCLOPENTA[CD]INDEN-7-YL)OXY)-BENZONITRILE AND POLYMORPHS THEREOF](/abs-image/US/2023/04/13/US20230115881A1/abs.jpg.150x150.jpg)
摘要：
The present disclosure provides certain processes of making 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)-benzonitrile (Compound 1) and certain polymorphs thereof. Also provided are pharmaceutical compositions comprising a crystalline polymorph form of Compound 1 and processes for preparing such polymorph forms.