The present disclosure provides a raw cannabis composition, the raw cannabis composition comprises a cannabis biomass dispersed in a transdermal carrier, and the cannabis biomass composition comprises an anesthetically effective amount of a cannabinoid acid compound and is substantially free from the cannabinoid acid compound in its decarboxylated form. The cannabinoid acid compound comprises a major cannabinoid acid compound that is tetrahydrocannabinolic acid (“THCA”) and a minor cannabinoid acid compound other than THCA. Methods of making and using the raw cannabis composition are also disclosed.