A computer-implemented method for multi-user multiplexing for block transmissions by an electronic device includes generating a user signal that includes a number of first samples in the time domain. The number of first samples are generated based on a discrete-time baseband signal and a predetermined guard period. A discrete Fourier transform (DFT) operation is performed on the number of first samples to obtain a number of second samples in the frequency domain. An interleaving operation is performed on the number of second samples to obtain a number of third samples in the frequency domain. An inverse-DFT (IDFT) operation is performed on the number of third samples to obtain a number of fourth samples in the time domain. A time shifting is performed on the number of fourth samples to obtain a number of shifted fourth samples. A block transmission is sent using the number of shifted fourth samples.