Climate control systems and methods of operating them are provided that circulate a working fluid including a high glide refrigerant blend having first and second refrigerants with a difference in boiling points ≥about 25° F. at atmospheric pressure. The system includes a gas-liquid separation vessel that generates a vapor stream and a liquid stream. A compressor receives the vapor stream and generates a pressurized vapor stream. A liquid pump receives the liquid stream and generates a pressurized liquid stream. A condenser is disposed downstream of the compressor and liquid pump and receives and cools the pressurized mixed vapor and liquid stream. An evaporator receives and at least partially vaporizes the multiphase working fluid and directs it to the gas-liquid separating vessel. An expansion device between the condenser and the evaporator processes the multiphase working fluid stream. Lastly, a fluid conduit for circulating the working fluid through the components is provided.