The present disclosure provides a setting method of a display panel and the display panel, the method includes: acquiring a first chromaticity information of a first gray scale and a second chromaticity information of a second gray scale; acquiring a first difference value between the first chromaticity information and the second chromaticity information; and adjusting gray scale voltages of the first gray scale and/or the second gray scale when the first difference value is greater than a preset difference threshold, and a second difference value between the first chromaticity information and the second chromaticity information after adjustment is less than the first difference value.