Various approaches for configuring interleaving in a memory pool used in an edge computing arrangement, including with the use of infrastructure processing units (IPUs) and similar networked processing units, are disclosed. An example system may discover and map disaggregated memory resources at respective compute locations connected to each another via at least one interconnect. The system may identify workload requirements for use of the compute locations by respective workloads, for workloads provided by client devices to the compute locations. The system may determine an interleaving arrangement for a memory pool that fulfills the workload requirements, to use the interleaving arrangement to distribute data for the respective workloads among the disaggregated memory resources. The system may configure the memory pool for use by the client devices of the network, as the memory pool causes the disaggregated memory resources to host data based on the interleaving arrangement.