Various approaches for service mech switching, including the use of infrastructure processing units (IPUs) and similar networked processing units, are disclosed. For example, a packet that includes a service request for a service may be received at a networking infrastructure device. The service may include an application that spans multiple nodes in a network. An outbound interface of the networking infrastructure device may be selected through which to route the packet. The selection of the outbound interface may be based on a service component of the service request in the packet and network metrics that correspond to the service. The packet may then be transmitted using the outbound interface.