- 专利标题： MODELS AND METHODS TO ESTABLISH PERFUSABLE, COMPARTMENTALIZED, LYMPHOID TISSUE MODELS IN THREE-DIMENSIONAL IN VITRO CULTURE
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申请号： US17979209申请日： 2022-11-02
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公开(公告)号： US20230138186A1公开(公告)日： 2023-05-04
- 发明人: James B. Hoying , Hannah A. Strobel , Sarah Moss
- 申请人： Advanced Solutions Life Sciences, LLC
- 申请人地址： US KY Louisville
- 专利权人： Advanced Solutions Life Sciences, LLC
- 当前专利权人： Advanced Solutions Life Sciences, LLC
- 当前专利权人地址： US KY Louisville
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; C12N5/0781 ; C12M1/00 ; C12M3/06 ; C12N5/0783 ; C12P21/00
摘要：
A three-dimensional (3D) lymphoid tissue model is provided, the model including a cellularized stromal compartment and a plurality of cellularized compartments including lymphocytes disposed within the stromal compartment; and a controlled fluid perfusion system configured to perfuse the model with a perfusion fluid. Methods of fabricating a 3D lymphoid tissue model and producing antibodies with the 3D lymphoid tissue model are also provided.