- 专利标题： METHODS OF ISOLATING T-CELLS AND T-CELL RECEPTORS FROM TUMOR BY SINGLE-CELL ANALYSIS FOR IMMUNOTHERAPY
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申请号： US17912315申请日： 2021-03-19
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公开(公告)号： US20230138309A1公开(公告)日： 2023-05-04
- 发明人: Sri Krishna , Frank J. Lowery, III , Ken-ichi Hanada , James C. Yang , Steven A. Rosenberg , Paul F. Robbins , Rami Yoseph
- 申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America,as represented by the Secretary,Department of Health and Human Services
- 当前专利权人： The United States of America,as represented by the Secretary,Department of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 国际申请： PCT/US2021/023240 WO 20210319
- 主分类号： C12N15/10
- IPC分类号： C12N15/10 ; C12N5/0783 ; C12Q1/6881
摘要：
Provided are methods of preparing an enriched population of T cells having antigenic specificity for a target antigen. The method may comprise isolating T cells from a tumor sample of a patient; selecting the isolated T cells which have a gene expression profile; and separating the selected T cells from the unselected cells. The separated selected T cells provide an enriched population of T cells having antigenic specificity for the target antigen. Methods of isolating a T cell receptor (TCR), preparing a population of cells that express a TCR, isolated TCRs, isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing a condition in a mammal are also provided.
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