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发明申请
US20230139890A1 FUSION PROTEIN COMPRISING IL-2 PROTEIN AND CD80 PROTEIN FRAGMENT OR VARIANT THEREOF, AND USES THEREOF 有权

  • 专利标题： FUSION PROTEIN COMPRISING IL-2 PROTEIN AND CD80 PROTEIN FRAGMENT OR VARIANT THEREOF, AND USES THEREOF
  • 申请号： US17912403
    申请日： 2021-03-18
  • 公开(公告)号： US20230139890A1
    公开(公告)日： 2023-05-04
  • 发明人: Myoung Ho JANG , Jae Chan PARK
  • 申请人： GI INNOVATION, INC.
  • 申请人地址： KR Seoul
  • 专利权人： GI INNOVATION, INC.
  • 当前专利权人： GI INNOVATION, INC.
  • 当前专利权人地址： KR Seoul
  • 优先权： KR10-2020-0033232 20200318,KR10-2020-0034031 20200319
  • 国际申请： PCT/KR2021/003334 WO 20210318
  • 主分类号： C07K14/55
  • IPC分类号： C07K14/55 ;  C07K14/705 ;  C12N15/63
FUSION PROTEIN COMPRISING IL-2 PROTEIN AND CD80 PROTEIN FRAGMENT OR VARIANT THEREOF, AND USES THEREOF
摘要：
The present invention relates to a fusion protein dimer comprising a modified IL-2 protein and a CD80 protein fragment or a variant thereof. The fusion protein comprising an IL-2 protein and a CD80 protein fragment or a variant thereof can not only activate immune cells owing to IL-2, but also effectively regulate Treg cells owing to CD80. Therefore, the fusion protein can efficiently attack cancer cells, and thus can be usefully employed for treatment of cancer or an infectious disease.
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