Provided are a driving method of a touch display panel, a driving circuit and a touch display device. The driving method includes: obtaining a touch position of an active stylus; determining a first region on the touch display panel based on the touch position of the active stylus; and transmitting an uplink (UL) signal to touch sensing electrodes in the first region and transmitting an anti-interference signal to the touch sensing electrodes in at least a part of the region except for the first region on the touch display panel during an UL transmission period, wherein the UL signal transmitted to the touch sensing electrodes in the first region during the UL transmission period is for transmission to the active stylus.