- 专利标题： DNA ENCODED NANOPARTICLES AND METHOD OF USE THEREOF AS A CORONAVIRUS DISEASE 2019 (COVID-19) VACCINE
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申请号： US18251620申请日： 2021-11-03
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公开(公告)号： US20240009300A1公开(公告)日： 2024-01-11
- 发明人: Daniel Kulp , Ziyang Xu , David Weiner
- 申请人： The Wistar Institute of Anatomy and Biology
- 申请人地址： US PA Philadelphia
- 专利权人： The Wistar Institute of Anatomy and Biology
- 当前专利权人： The Wistar Institute of Anatomy and Biology
- 当前专利权人地址： US PA Philadelphia
- 国际申请： PCT/US21/57859 2021.11.03
- 进入国家日期： 2023-05-03
- 主分类号： A61K39/215
- IPC分类号： A61K39/215 ; A61P31/14 ; C07K14/165
摘要：
Disclosed herein are nanoparticles comprising one or more SARS coronavirus 2 (SARS-CoV-2) Spike receptor binding domain (RBD) antigen and nucleic acid molecules encoding the same. Also disclosed herein is a method of treating a SARS-COV-2 infection or treating or preventing a disease or disorder associated therewith in a subject in need thereof, by administering the nanoparticles, or encoding nucleic acid molecules, to the subject.
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