The present disclosure belongs to the field of photoacoustic signal detection, and specifically relates to a quantum-enhanced all-optical photoacoustic signal detection device and method. The problem of low sensitivity of photoacoustic signals based on interference measurement is solved, and high-sensitivity detection of photoacoustic signals generated by living organisms including human bodies can be achieved. A degenerate optical parametric oscillator based on a first-type phase matching crystals is used for preparing a vacuum squeezed state light field, a coherent control technology is used for locking the squeezed angle to obtain the quadrature phase vacuum squeezed state, the prepared quadrature phase vacuum squeezed state light field is injected into the vacuum channel of a Michelson interferometer, and a balanced homodyne detection mode is used for achieving detection of the quantum-enhanced photoacoustic signals.