- 专利标题： PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS
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申请号： US18124071申请日： 2023-03-21
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公开(公告)号： US20240083901A1公开(公告)日： 2024-03-14
- 发明人: Anna ERICSSON , Neal GREEN , Gary GUSTAFSON , Bingsong HAN , David R. LANCIA, JR. , Lorna MITCHELL , David RICHARD , Tatiana SHELEKHIN , Chase C. SMITH , Zhongguo WANG , Xiaozhang ZHENG
- 申请人： FORMA Therapeutics, Inc.
- 申请人地址： US MA Watertown
- 专利权人： FORMA Therapeutics, Inc.
- 当前专利权人： FORMA Therapeutics, Inc.
- 当前专利权人地址： US MA Watertown
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K9/00 ; A61K31/407 ; A61P7/00 ; C07D519/00
摘要：
The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.
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