- 专利标题： Antibodies Binding to VISTA at Acidic pH
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申请号： US18162991申请日： 2023-02-01
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公开(公告)号： US20240092907A1公开(公告)日： 2024-03-21
- 发明人: Robert J. Johnston , Arvind Rajpal , Paul O. Sheppard , Luis Borges , Andrew Rankin , Keith Sadoon Bahjat , Alan J. Korman , Andy X. Deng , Lin Hui Su , Ginger Rakestraw
- 申请人： Five Prime Therapeutics, Inc. , Bristol-Myers Squibb Company
- 申请人地址： US CA Thousand Oaks
- 专利权人： Five Prime Therapeutics, Inc.,Bristol-Myers Squibb Company
- 当前专利权人： Five Prime Therapeutics, Inc.,Bristol-Myers Squibb Company
- 当前专利权人地址： US CA Thousand Oaks; US NJ Princeton
- 分案原申请号： US16493712 2019.09.12
- 主分类号： C07K16/28
- IPC分类号： C07K16/28
摘要：
The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
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