Invention Publication
- Patent Title: OLIGONUCLEOTIDE-TETHERED NUCLEOTIDES
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Application No.: US18345856Application Date: 2023-06-30
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Publication No.: US20240102003A1Publication Date: 2024-03-28
- Inventor: Arvydas Lubys , Inga Cikotiene , Zana Kapustina , Arturas Berezniakovas , Justina Sulgaite , Simona Zeimyte , Mark Andersen , Michael Allen , Sihong Chen
- Applicant: Thermo Fisher Scientific Baltics UAB , Life Technologies Corporation
- Applicant Address: LT CA Vilnius
- Assignee: Thermo Fisher Scientific Baltics UAB,Life Technologies Corporation
- Current Assignee: Thermo Fisher Scientific Baltics UAB,Life Technologies Corporation
- Current Assignee Address: LT Vilnius; US CA Carlsbad
- The original application number of the division: US16908567 2020.06.22
- Main IPC: C12N15/10
- IPC: C12N15/10 ; C12N15/115 ; C12Q1/6806

Abstract:
The present disclosure describes oligonucleotide-tethered nucleotides, methods of making them, and methods of using them. The oligonucleotide-tethered nucleotides comprise, in some embodiments, a nucleotide linked to an oligonucleotide of from about 3 to about 100 nucleotides in length. These oligonucleotide-tethered nucleotides can be used to label a plurality of different types of nucleic acids in a plurality of different situations with a known oligonucleotide, which can serve as a barcode in some embodiments. The resulting oligonucleotide-labeled nucleic acids oligo-nucleotides can be used in a variety of nucleic acid sequencing methods.
Information query
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