Methods and apparatus for calibration of a second-order input intercept point (IIP2) of a mixer, such as a mixer in a wireless receive chain. One example circuit for mixer IIP2 calibration generally includes a first receive chain comprising a first mixer and a single tone generator having an output coupled to an input of the first mixer and configured to generate a calibration signal having a single baseband tone. One example method of mixer IIP2 calibration generally includes generating a calibration signal comprising a single baseband tone, applying the calibration signal to an input of a mixer, such that the mixer generates a differential tone at an output of the mixer, and adjusting the mixer to minimize a power of the differential tone at the output of the mixer.