发明公开
- 专利标题： COMPOSITIONS AND METHODS FOR REVERSING AGE-ASSOCIATED DENDRITIC SPINE LOSS
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申请号： US18464725申请日： 2023-09-11
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公开(公告)号： US20240108595A1公开(公告)日： 2024-04-04
- 发明人: Robert A. SWEET , Brandon C. MCKINNEY , LiRong WANG , Matthew Luke MACDONALD , Peihao FAN , Joshua Michael KRIVINKO
- 申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , UNIVERSITY OF PITTSBURGH MEDICAL CENTER
- 申请人地址： US PA Pittsburgh
- 专利权人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION,UNIVERSITY OF PITTSBURGH MEDICAL CENTER
- 当前专利权人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION,UNIVERSITY OF PITTSBURGH MEDICAL CENTER
- 当前专利权人地址： US PA Pittsburgh
- 主分类号： A61K31/221
- IPC分类号： A61K31/221 ; A61K31/42 ; A61K31/436 ; A61K31/497 ; A61K31/506 ; A61K31/519 ; A61K31/5685 ; A61K31/737 ; A61P25/28
摘要：
Described herein are methods of treating, preventing, or reducing dendritic spine density loss in a subject, the method comprising administering a compound selected from: metformin, pentosan polysulfate, amlexanox, leflunomide, prasterone, glutathione disulfide, pazopanib, bosutinib, dabrafenib, baricitinib, or a pharmaceutically acceptable salt, prodrug, or derivative thereof; or any combination thereof; or compositions described herein.
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