Invention Publication
- Patent Title: METHODS FOR REDUCING PATHOGENIC E COLI BY SELECTIVE FEED ADDITIVE INTERVENTION COMPRISING ENZYMES SUCH AS MURAMIDASE
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Application No.: US18263818Application Date: 2022-02-15
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Publication No.: US20240115669A1Publication Date: 2024-04-11
- Inventor: Joshua CLAYPOOL , Kevin FREEMAN , Ghislain SCHYNS
- Applicant: DSM IP Assets B.V. , NOVOZYMES A/S
- Applicant Address: NL Heerlen
- Assignee: DSM IP Assets B.V.,NOVOZYMES A/S
- Current Assignee: DSM IP Assets B.V.,NOVOZYMES A/S
- Current Assignee Address: NL Heerlen
- International Application: PCT/EP2022/053673 2022.02.15
- Date entered country: 2023-08-01
- Main IPC: A61K38/48
- IPC: A61K38/48 ; A61K9/00 ; A61K38/44 ; A61K38/47 ; A61P31/04 ; C12Q1/689
Abstract:
The present disclosure relates to methods of modulating level of E. coli present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level of LEE and non-LEE pathogenic genes in the microbiome of the host animal. The present disclosure further relates to methods of modulating the virulence of pathogenic E. coli in the gastrointestinal tract of an animal by reducing the population of B. thetaiotaomicron in the gut microbiome of the animal.
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