A two-wheeled vehicle pneumatic tire having a tread, a tire carcass, tire sidewalls, and two bead regions with a bead protective strip. The tire carcass is formed from a first carcass inlay and a second carcass inlay. The second carcass inlay is arranged radially inwardly of the first carcass inlay, and extends from a crown region (17) of the two-wheeled vehicle pneumatic tire and terminates at a second carcass inlay end under the bead protective strip. The two-wheeled vehicle pneumatic tire provides improved puncture protection whilst maintaining good rolling resistance. This is achieved in that the first carcass inlay is guided with a first carcass inlay turn-up over the particular tire sidewall as far as under the tread to a first carcass inlay end, and terminates there at the first carcass inlay end.