Provided is a disease prediction method and apparatus. The disease prediction apparatus may receive a medical image and clinical information, identify, from the medical image, quantitative data comprising a volume of at least one anatomical structure, and predict a disease occurrence based on the clinical information and the quantitative data. An artificial intelligence model may be used for each of identification of an anatomical structure and prediction of the disease occurrence. The disclosure was supported by the “AI Precision Medical Solution (Doctor Answer 2.0) Development” project hosted by Seoul National University Bundang Hospital (Project Serial No.: 1711151151, Project No.: S0252-21-1001).