Provided are a display panel, a driving method of a display panel, and a display device. The display panel includes a first display region and a second display region. A working process of the display panel includes a first mode. In the first mode, a data refresh rate of the first display region is F11, a data refresh rate of the second display region is F21, and F11≠F21. In the first mode, a driving parameter of the first display region is different from a driving parameter of the second display region, the driving parameter of the first display region is used for controlling brightness of the first display region, and the driving parameter of the second display region is used for controlling brightness of the second display region.