The present technology relates to an information processing system, an information processing method, and a program that enable to hold an event in consideration of infection suppression of infectious diseases. Included are: an acquisition unit configured to acquire ticket information including an attribute of a ticket in an event, user information related to an infectious disease of a user, and event information set by a manager of the event; a determination unit configured to make a determination on the basis of the user information and the setting information; and a setting unit configured to set an attribute of the ticket on the basis of a determination result. The present technology can be applied to, for example, a management server that manages events.