The present disclosure relates to a reinforced thermoplastic bag with lofted regions. In one or more embodiments, the reinforced thermoplastic bag includes a reinforced portion with lofted regions at a top-of-bag area where users often apply an external force to lift or carry the reinforced thermoplastic bag. In these or other embodiments, a reinforcing strip is positioned across one or both of a hem channel region and a grab zone along an outer surface, an inner surface, or between layers of the reinforced thermoplastic bag. In one or more embodiments, the lofted regions increase the loft of the reinforced thermoplastic bag, improve the feel of the reinforced thermoplastic bag, and/or modify a look of the reinforced thermoplastic bag.