A ferritin protein according to an embodiment of the present disclosure has an outer surface on which a molecule configured to bind to an immune checkpoint molecule. The present invention relates to a protein used with a disease antigen and a use of same. The A ferritin protein is formed via self-assembly of ferritin monomers fused with a disease antigen epitope. The protein exhibits excellent binding affinity to a human transferrin receptor, and thus can provide various kinds of disease antigen epitopes with different lengths to antigen-presenting cells so as to induce an immune response to the corresponding antigen.