Invention Publication
- Patent Title: Small Molecule Degraders of CBP/p300 Proteins
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Application No.: US18279232Application Date: 2022-03-03
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Publication No.: US20240150360A1Publication Date: 2024-05-09
- Inventor: Shaomeng Wang , Zhixiang Chen , Dimin Wu , Mi Wang
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- International Application: PCT/US22/18597 2022.03.03
- Date entered country: 2023-08-29
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D401/04 ; C07D471/04 ; C07D519/00
Abstract:
The present disclosure relates to compounds of Formula (I), and the pharmaceutically
A—(CH2)m—X—Y—Z—B1 I,
acceptable salts and solvates thereof, wherein A, m, X, Y, Z, and B1 are as defined as set forth in the specification. The present disclosure also relates to uses of the compounds, e.g., in treating or preventing a condition or disorder responsive to the degradation of CBP/P300 proteins (e.g., cancer).
A—(CH2)m—X—Y—Z—B1 I,
acceptable salts and solvates thereof, wherein A, m, X, Y, Z, and B1 are as defined as set forth in the specification. The present disclosure also relates to uses of the compounds, e.g., in treating or preventing a condition or disorder responsive to the degradation of CBP/P300 proteins (e.g., cancer).
Information query
