PRODRUGS AND COMPOSITIONS FOR OPHTHALMOLOGY APPLICATIONS
Abstract:
The present disclosure is directed to prodrugs, compositions including prodrugs, and methods for administering prodrugs and compositions thereof to a patient, including prodrugs represented by Formula (I):




wherein: D is a drug moiety; Q is an oxygen atom, a sulfur atom, or a nitrogen atom; X is a chemical bond or




each of G, G′, and G″ is independently an oxygen atom or a sulfur atom; L is a polyether; T is a hydrogen atom, a hydroxyl group, a thiol group, a boronic acid group, or an amine group; R1 is selected from the group consisting of a substituted aryl group, unsubstituted aryl group, and a substituted carbonyl group; and each of R2, R3, R1′, R2′, R3′, and R4′ is independently a hydrogen atom, a substituted C1-C20 alkyl group, or an unsubstituted C1 -C20 alkyl group. In at least one embodiment, a composition comprises a compound and a carrier material.
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