Systems and methods are described for efficiently processing events related to a relationship between a primary copy of data at a primary storage system and a mirror copy of the data at a cross-site secondary storage system of a multi-site distributed storage system. According to an example, a mediator agent that is configured on both primary and secondary storage systems provides coordination and serialization for various events generated in the relationship. The multi-site distributed storage system performs actions based on the event processing such as performing a failover operation from the primary storage system to the secondary storage system or resynchronizing the relationship to ensure application protection and availability.