An example system and method may manage interference for wireless devices in a non-terrestrial network environment. An example system may determine spectrum blanking ranges for a wireless client device, where the spectrum blanking range restricts wireless frequencies in the spectrum blanking range from being assigned to wireless client devices by ground node. The system may determine a signal quality indicator value for a wireless client device, determine an assignable spectrum range for the wireless client device based on the signal quality indicator value and the spectrum blanking range(s), and assign a channel to the wireless client device using the assignable spectrum range.