A cabinet that securely stores items in cabinet drawers using preconfigured nests. The drawers can be reconfigured using one or more dividers to divide the drawers into two or more compartments. The cabinet has cameras mounted to it and uses images to determine if a compartment contains an item and other information. In some embodiments, features are implemented to closely monitor the self-serve access and removal of items from the cabinet. Features can include the incorporation of serialization of items and automated tracking of items in a bulk item stocked in the cabinet. Features can also include multimode access such as allowing users to quickly access contents of the cabinet while for example providing graphical illustrations based on information about the stock in a supporting database.