- 专利标题: TISSUE-SPECIFIC NUCLEIC ACID DELIVERY BY MIXED CATIONIC LIPID PARTICLES
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申请号: US18556563申请日: 2022-04-21
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公开(公告)号: US20240197636A1公开(公告)日: 2024-06-20
- 发明人: Vishwesh Ashok Patil , Can Sarisozen , Daniel Ferreira Gomes Costa
- 申请人: OMEGA THERAPEUTICS, INC.
- 申请人地址: US MA Cambridge
- 专利权人: OMEGA THERAPEUTICS, INC.
- 当前专利权人: OMEGA THERAPEUTICS, INC.
- 当前专利权人地址: US MA Cambridge
- 国际申请: PCT/US2022/025674 2022.04.21
- 进入国家日期: 2023-10-20
- 主分类号: A61K9/16
- IPC分类号: A61K9/16 ; A61K47/54 ; A61P1/16 ; C12N15/113
摘要:
The instant disclosure relates to nucleic acid-lipid particles that mix ionizable and cationic lipids, which preferentially localize and deliver associated cargoes to the liver when administered parenterally, and which optionally can be used to deliver associated cargoes to tissues to which such particles are directly injected. The instant disclosure provides compositions comprising such lipid particles, optionally in association with a therapeutic agent (e.g., a therapeutic mRNA and/or nucleic acid controller system), as well as methods and kits for delivering a lipid particle-associated therapeutic agent and/or treating a disease or disorder, e.g., a liver disease or disorder, in a subject, using the lipid particle compositions provided herein.
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