- 专利标题： COMPOSITIONS AND METHODS FOR TREATING RETINAL DEGENERATIVE DISORDERS
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申请号： US18287758申请日： 2022-04-20
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公开(公告)号： US20240197913A1公开(公告)日： 2024-06-20
- 发明人: Deniz DALKARA , Hanen KHABOU , Florence LORGET , José SAHEL , Simon CARDILLA-JOE
- 申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , SPARINGVISION , CENTRE NATIONAL DE LA RECHERCHE SCIENFITIQUE - CRNS - , SORBONNE UNIVERSITE
- 申请人地址： FR Paris
- 专利权人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),SPARINGVISION,CENTRE NATIONAL DE LA RECHERCHE SCIENFITIQUE - CRNS -,SORBONNE UNIVERSITE
- 当前专利权人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),SPARINGVISION,CENTRE NATIONAL DE LA RECHERCHE SCIENFITIQUE - CRNS -,SORBONNE UNIVERSITE
- 当前专利权人地址： FR Paris
- 优先权： EP 169473.2 2021.04.20
- 国际申请： PCT/EP2022/060462 2022.04.20
- 进入国家日期： 2023-10-20
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K9/00 ; A61K38/17 ; C12N15/86
摘要：
The present invention relates to the combination of a nucleic acid encoding a short isoform of rod-derived cone viability factor (RdCVF), a nucleic acid encoding a long isoform of rod-derived cone viability factor (RdCVFL) and a nucleic acid encoding a G protein-activated Inward Rectifier potassium channel 2 (GIRK2), expressed through one, two or three viral vectors, said vectors may be within a single pharmaceutical composition or within several different pharmaceutical compositions (two or three). It also deals with the treatment of a retinal degenerative disease, in particular the retinitis pigmentosa, with said viral vectors or pharmaceutical compositions.
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