Methods, systems, and computer program products for configuring artificial intelligence-based virtual assistants using response modes are provided herein. A computer-implemented method includes configuring multiple response modes in connection with at least one artificial intelligence-based virtual assistant, each response mode corresponding to a respective set of operational settings for the at least one artificial intelligence-based virtual assistant; implementing, for the at least one artificial intelligence-based virtual assistant, one of the multiple response modes based at least in part on at least one user request submitted to the at least one artificial intelligence-based virtual assistant and one or more items of data associated with the at least one artificial intelligence-based virtual assistant; and configuring at least one workflow to be carried out by the at least one artificial intelligence-based virtual assistant in response to the at least one user request and in accordance with the implemented response mode.