- 专利标题: METHODS AND COMPOSITIONS COMPRISING MHC CLASS I PEPTIDES
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申请号: US18556054申请日: 2022-04-18
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公开(公告)号: US20240207406A1公开(公告)日: 2024-06-27
- 发明人: Cassian YEE , Ke PAN , Yulun CHIU
- 申请人: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- 申请人地址: US TX Austin
- 专利权人: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- 当前专利权人: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- 当前专利权人地址: US TX Austin
- 国际申请: PCT/US2022/025223 2022.04.18
- 进入国家日期: 2023-10-18
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; A61K45/06 ; C07K7/06 ; C07K14/725 ; C07K14/74 ; C07K16/32 ; C12N5/0783 ; C12N15/115 ; G01N33/569
摘要:
The current disclosure fulfills a need in the art by providing methods and compositions for treating and vaccinating individuals against cancer. Accordingly, aspects of the disclosure relate to an isolated peptide comprising at least 70% sequence identity to a peptide of SEQ ID NO: 1 or 2. In some embodiments, the peptide comprises at least 6 contiguous amino acids of a peptide of SEQ ID NO:1 or 2. Further aspects relate to pharmaceutical compositions comprising the isolated peptide, nucleic acids encoding the peptide, and expression vectors and host cells comprising the nucleic acids of the disclosure. Also provided is an in vitro isolated dendritic cell comprising a peptide, nucleic acid, or expression vector of the disclosure.
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