The present invention proposes a composition for controlling pest rodents, the composition comprising: a) at least one direct coagulation factor inhibitor and b) at least one P-glycoprotein inhibitor (p-GP inhibitor). Through the composition, it is possible to achieve that existing resistances in pest rodents can be circumvented and at the same time a good effect can be achieved with a lower dosage, which can result in a comparatively more environmentally friendly application.