Embodiments of the present disclosure provide a display substrate, a driving method therefor, and a display apparatus. The display substrate has a display area and a bezel area. The display area includes a first display area and a second display area. The first display area has a light transmittance higher than that of the second display area. The first display area includes a plurality of pixel units distributed in an array, each pixel unit including a first subpixel and a second subpixel emitting different colors of light. The first display area includes a first initialization voltage line and a second initialization voltage line. The first initialization voltage line is electrically connected to the first subpixel, the second initialization voltage line is electrically connected to the second subpixel, and the first initialization voltage line and the second initialization voltage line are configured to receive different initialization voltages.