发明公开
- 专利标题: CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR BAFF-R AND CD19 AND METHODS AND USES THEREOF
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申请号: US18537696申请日: 2023-12-12
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公开(公告)号: US20240226298A1公开(公告)日: 2024-07-11
- 发明人: Ruth Amanda SALMON , Douglas JONES , Brian BELMONT , Madeline WILLIAMS , Rebekah TURK , Eric William JEFFERY , Andres ALVAREZ , Yue JIANG , Gabriela DIAZ , Thomas COX , Chia-Yung WU , Tiffany HUELAR , Jon JONES , Stephanie BUSCH , Cedric CLEYRAT
- 申请人: Juno Therapeutics, Inc.
- 申请人地址: US WA Seattle
- 专利权人: Juno Therapeutics, Inc.
- 当前专利权人: Juno Therapeutics, Inc.
- 当前专利权人地址: US WA Seattle
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; A61K47/68 ; A61P35/00 ; C07K14/725 ; C07K16/28
摘要:
Provided are B cell-activating factor receptor (BAFF-R)-binding molecules, in particular, to human antibodies specific for BAFF-R, including antibody fragments. The present disclosure further relates to recombinant receptors, including chimeric antigen receptors (CARs) that contain such antibodies or fragments, and polynucleotides that encode the antibodies, antigen-binding fragments or receptors specific for BAFF-R. Also provided are CARs which contain extracellular binding domains that bind to BAFF-R and B-lymphocyte antigen CD19 (CD19), genetically engineered cells expressing such CARs, and uses thereof in adoptive cell therapy.
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